take a toll

take a toll (on sb) AND take its/their toll (on sb) (cause harm or suffering; be damaging or harmful, cause loss or destruction) — cказаться; иметь негативные последствия; дурно повлиять на что-л.; сыграть свою роль; сделать свое дело; не пройти даром; оставить свой след, не пройти бесследно (о последствиях вредного воздействия, трудностей)

Example 1: I'm exhausted. Three years overseas working nonstop has taken its toll (on me). I need a vacation.

Example 2: She felt tired and flat; the strain of the past thirty days was taking its toll.

Example 3: Day after day, week after week, the lack of sleep takes its toll (on your psyche).

Example 4: They started seeing less of each other, and it was starting/beginning to take a toll.

Example 5: Human beings are amazingly resilient and can stand almost anything, though the mental and psychological exhaustion takes its toll.

Example 6: Three days with almost no sleep had taken their toll, so Grant was semi-dozing in his seat when Carolina's voice brought him back to reality. (Eric James Stone, "Resonance")

Example 7: As we heard from Dr. Insel this morning, psychiatric disorders like autism, depression and schizophrenia take a terrible toll on human suffering. We know much less about their treatment and the understanding of their basic mechanisms than we do about diseases of the body.(David Anderson, Your brain is more than a bag of chemicals)

take a (great/heavy/terrible/etc/) toll (of sth) — наносить тяжелый урон (чему-л.)

Example 1: Rent takes a heavy toll of their income. — Арендная плата съедает значительную часть их доходов

Example 2: Accidents take a heavy toll of human lives.
— Катастрофы уносят много человеческих жизней

Example 3: People overestimate the frequency of the dramatic causes of death and underestimate the undramatic and unpublicised killers which actually take a greater toll of life. ~ уносят больше жизней.