Shoot! (= go ahead; ask your questions) — Выкладывай!; Не тяни! Говори!

Example 1:
"Can I ask you a few questions about applying to graduate schools?" "Well, I don't know much about it, but shoot."

Example 2: "Do you mind if I ask you a couple of questions now that we’re on the phone though? "I just got a minute, but, shoot."

See also
[fire away]