avoid like the plague

avoid like a plague (to try very hard to avoid someone or something that you do not like ) — бежать как от огня, как от чумы; избегать всеми силами; ~ обходить за версту

Example 1: I'm not a fan of parties — in fact I avoid them like the plague.

Example 2: She used to avoid responsibility like the plague.

======
A plague is a serious disease which kills many people.

see also
[run a mile]
[steer clear]
[not touch sth with a ten-foot pole]
[give a wide berth]