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There are a lot of English idioms and other words and
expressions that can be used (often humorously, but not politely) to describe someone who is mad or insane, or who behaves in a mad way. Here are a few:
...barmy; bonkers;
...off his / her rocker;
...out of his / her tree;
...dotty; potty; batty;
...out to lunch;
...round the bend;
...stark staring bonkers;
...stark raving mad;

a nutcase; a nutter;
a basket case; a fruitcake; as nutty as a fruitcake;
as mad as a hatter; as mad as a March hare; as mad as a box of frogs;
a loony; a crackpot;

he's / she's lost his /her marbles; he's / she's got toys in the attic; gaga; doolally (these last four areoften used to describe old people who are going senile)

Be very careful how and when you use these words and expressions: they are not considered acceptable in many situations, and some people might be offended by them.

See also

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(Related Clichés)
A few clowns short of a circus.
A few fries short of a Happy Meal.
An experiment in Artificial Stupidity.
A few beers short of a six-pack.
A few bricks short of a full load;
A few bricks shy.
A few cards short of a full deck;
A few fries short of a happy meal
A few peas short of a casserole.
A few/two sandwiches short of a picnic
A few feathers short of a whole duck.
A Half a bubble off
All foam, no beer.
An intellect rivaled only by garden tools.
As smart as bait.

Body by Fisher, brains by Mattel.
Chimney's clogged.
Couldn't find his way out of a paper bag
Couldn't pour water out of a boot with instructions on the heel.
Doesn't have both oars in the water
Doesn't have all her cornflakes in one box.
Doesn't have all his dogs on one leash.
Doesn't know much but leads the league in nostril hair.
Dumb as a post
Dumb as a stump
Dumber than a bag of hammers
Dumber than a box of rocks
Dumber than a box of hair.
Elevator doesn't go all the way to the top floor.
Forgot to pay her brain bill.
Her sewing machine's out of thread.
His antenna doesn't pick up all the channels.
His belt doesn't go through all the loops.
His/Her elevator doesn't go all the way to the top floor
If she had another brain, it would be lonely.
Just fell off the turnip truck
Missing a few buttons on his remote control.
No grain in the silo.
Not the sharpest knife in the drawer /in the cabinet
Not playing with a full deck
Not the brightest bulb (in the box / on the tree / in the chandelier)
Not the brightest crayon in the box
Not the sharpest crayon in the box
Not the sharpest pencil in the box
One Fruit Loop shy of a full bowl.
One taco short of a combination plate.
Proof that evolution CAN go in reverse.
Receiver is off the hook.
Several nuts short of a full pouch.
Sharp as a marble
Skylight leaks a little.
Slinky's kinked.
Surfing in Nebraska.
Too much yardage between the goal posts.
The cheese slid off her cracker.
The lights are on, but nobody's home.
24 cents short of a quarter.
The wheel's spinning /turning, but the hamster's dead.
Thick as a brick
Thick as a ditch